Epigenetics, genomic imprinting and psychiatric illness
نویسندگان
چکیده
منابع مشابه
Implications of genomic imprinting for psychiatric genetics.
The genetics of psychiatric disease continues to be puzzling; what, for instance, really is the mode of transmission of schizophrenia? Is it polygenic (Gottesman & Shields, 1982)? Is it dominant but incompletely penetrant (Book, 1953), or partly dominant with incomplete penetrance (Slater, 1958); does it involve two loci with epistasis (Matthysse & Kidd, 1976), or is it none of these (O'Rourke ...
متن کاملImplications of genomic imprinting for psychiatric genetics
The genetics of psychiatric disease continues to be puzzling; what, for instance, really is the mode of transmission of schizophrenia? Is it polygenic (Gottesman & Shields, 1982)? Is it dominant but incompletely penetrant (Book, 1953), or partly dominant with incomplete penetrance (Slater, 1958); does it involve two loci with epistasis (Matthysse & Kidd, 1976), or is it none of these (O'Rourke ...
متن کاملMolecular Epigenetics and Development: Histone Conformations, DNA Methylation and Genomic Imprinting
Introduced by Conrad Hal Waddington [3] in 1942, the concept of epigenetics [4] gave scientists a new paradigm of thought concerning embryonic development, and since then has been widely applied, for instance to inheritable diseases, molecular technologies, and indeed the human genome [5] as a whole. A genome [5] contains an embedded intricate coding template that provides a means of genetic ex...
متن کاملGenomic Imprinting
BACKGROUND Genomic imprinting is the inheritance out of Mendelian borders. Many of inherited diseases and human development violates Mendelian law of inheritance, this way of inheriting is studied by epigenetics. AIM The aim of this review is to analyze current opinions and options regarding to this way of inheriting. RESULTS Epigenetics shows that gene expression undergoes changes more com...
متن کاملEpigenetics and imprinting in human disease.
Most genes are expressed from both parental chromosomes; however, a small number of genes in mammals are imprinted and expressed in a parent-of-origin specific manner. These imprinted genes play an important role in embryonic and extraembryonic growth and development, as well as in a variety of processes after birth. Many imprinted genes are clustered in the genome with the establishment and ma...
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ژورنال
عنوان ژورنال: IBRO Reports
سال: 2019
ISSN: 2451-8301
DOI: 10.1016/j.ibror.2019.07.090